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[Inclusion-body myositis: a familial report of 3 cases]. / Miositis con cuerpos de inclusión: presentación familiar de tres casos.

Inclusion body myositis (IBM) is a myopathy classified until now within the group of idiopathic inflammatory myopathies (IIM). Nevertheless, its clinical and histological features are specific and different from the other IIM. It is refractory to corticosteroid therapy. Recently, a few cases of IBM with familial transmission have been described, which is the first report in our country; previous reported cases in literature are reviewed. The similarities of some forms of IBM with muscle dystrophies, rather than with inflammatory myopathies are discussed.

[Thyrotoxic hypokalemic periodic paralysis]. / Parálisis periódica tireotóxica normocaliémica.

A case of palsy without family history associated to hyperthyroidism, is described. This is an rare entity in our environment (only two cases have been previously described) and may develop with hypo, normo or hyperkalemia. Its potential pathogenicity is discussed, which finally results in a disorder of the ionic interchange at the level of the muscle membrane. The need to identify these secondary forms of recurrent palsy is stressed, given that it may benefit from an adequate treatment. In the case presented here, the normalization of the thyroid function was followed by the sustained elimination of the muscle symptomatology.

[The behavior of a striated muscle implant in contact with the intestinal wall. An experimental study]. / Comportamiento de un implante de musculo estriado en contacto con la pared intestinal. Estudio experimental.

Based on the experiences of Thompson and Hakelius, we wanted to study the behaviour of a previously denervated skeletal muscle, in close contact with the intestinal wall, as a possible high pressure mechanism. We used 60 Sprague-Dawley rats. Two surgical procedures were performed: sciatic nerve section and a plantaris muscle transplant at the ileum, the interval between these two procedures was zero, two and four weeks. The implant area was studied by histochemical and histological techniques at different posttransplant times. Live muscle fibers were seen in all implants. The best results were seen in those implants that has been denervated 4 weeks prior to the seconds procedure. During the first phase, there was considerable postimplant inflammation. In the later phases, healthy muscle fiber remained, but with partial fibrous substitution. An implant of skeletal muscle, prior denervated, in contact with the intestinal wall, survive the posttransplant ischemia. The implant showed live muscle fibers with structural capacity for contraction. This experimental model, that is described for the first time, allows for the functional study of pre- and postimplant behaviour.

[Myositis with inclusion bodies: a little-known variety of idiopathic inflammatory myopathy]. / Miositis con cuerpos de inclusión: una variedad poco conocida de miopatía inflamatoria idiopática.

The authors report two male patients with inclusion body myositis (IBM) and review the features of this condition in the literature. This is an uncommon type of idiopathic myositis which involves males more often than females; it usually develops in elderly patients; its course is very slow; it is usually associated with distal weakness; neurophysiological studies show a mixed "myogenic" and "neurogenic" pattern; and it is usually unresponsive to corticosteroids. The diagnosis is basically made on the basis of the histological features, mainly consisting of vacuoles surrounded by a basophilic haze in histochemical stains of frozen tissue and, particularly, by the presence of characteristic microfilaments in ultrastructural studies.